CRP da Hs-CRP: Dual Dimensions of Inflammation Monitoring

C-reactive sunadaran (CRP), a matsayin core biomarker ga m kumburi da kamuwa da cuta, ta sosai m bambance-bambancen Hs-CRP (high-sensitivity C-reactive protein) ya kara fadada iyakokin aikace-aikace na asibiti. CRP na al'ada (tare da kewayon ganowa na 0.5 - 300 MG / L) yana mai da hankali kan sauri. Bincike na m cututtuka, postoperative rikitarwa, da sepsis, yayin da Hs-CRP (tare da gano kewayon 0.1 - 10 MG / L) iya daidai kama low-tatsuwa kumburi sigina, samar da mahimmin tushe ga m cututtuka na zuciya da jijiyoyin jini m stratification, na kullum kumburi management, da kuma nunawa na sub-lafiya yawan jama'a. Haɗin aikace-aikacen gano dual-nucleus yana samun cikakkiyar ɗaukar hoto daga mahimmancin magani na gaggawa zuwa rigakafin farko.

Yanayin aikace-aikacen asibiti na tushen shaida

1. Madaidaicin Ganowa da Tsare-tsare na Mai kamuwa da cuta Cututtuka

Haɗin haɗin gwiwa na CRP + PCT: Lokacin da aka haɗa CRP ≥ 50 mg / L tare da PCT ≥ 0.5 ng/mL, yana nuna kamuwa da ƙwayoyin cuta (ƙayyadaddun> 95%);

Rarrabe Cututtukan Kwayoyin cuta: Lokacin da CRP ya ɗan ƙara girma (10 - 40 mg / L) kuma PCT na al'ada ne, kamuwa da cutar hoto ko ƙwayar cuta ya kamata a yi la'akari da shi a matsayin fifiko.

2. Ƙimar Haɗari na Cututtukan Zuciya

Kulawa da Kumburi na yau da kullum: CRP ≥ 3 mg / L yana nuna ƙananan ƙananan ƙwayoyin cuta, wanda ke da alaƙa da haɗarin atherosclerosis;

Tsarin kimantawa na cututtukan zuciya na zuciya: A cikin marasa lafiya tare da m cronary syndrome, idan crp ya kasance an ɗaukaka shi (> 10 MG / L), yana ba da shawarar ci gaba mai kumburi da rashin ƙarfi.

3. Gudanar da Cututtukan Autoimmune

Dynamic tracking na aikin kumburi: Matsayin CRP a cikin marasa lafiya tare da Rheumatoid Arthritis yana da alaƙa da alaƙa da aikin cuta (ƙimar manufa: CRP

Ƙididdiga na maganin warkewa: A ≥ 50% raguwa a cikin CRP bayan ilimin ilimin halitta yana nuna kyakkyawar amsawar warkewa.

4. Bayan tiyata da kulawa mai zurfi

Gargadi na kamuwa da cuta bayan tiyata: Rage raguwa a matakin CRP kololuwa ko karuwa mai tsayi (> 100 mg / L) bayan tiyata yana nuna haɗarin rikitarwa;

Ganewar farko na sepsis: CRP> 100 mg / L hade tare da PCT ≥ 2 ng/mL na iya fara maganin rigakafin kamuwa da cuta da sauri.

5. Haɗarin Haɗari da Magungunan Rigakafi don Cututtukan Zuciya

Binciken mutanen asymptomatic: Hs-CRP ≥ 2 mg/L yana nuna ninki biyu na haɗarin abubuwan da ke faruwa na zuciya da jijiyoyin jini. Haɗe tare da bayanin martaba na lipid (irin su LDL-C), zai iya inganta ƙirar haɗarin haɗari (kamar yadda shawarar ACC / AHA jagororin);

Ƙimar tasirin shiga tsakani: Bayan jiyya na statin, Hs-CRP an rage zuwa

Ga mutane an ba da shawarar yanke hukunci game da cutar kumburi da CVD. Mai bi:

6. Gudanar da Cututtukan Metabolic na Zamani

Gargadi Rikicin Ciwon Ciwon sukari: Ci gaba da haɓaka Hs-CRP (> 3 mg / L) a cikin marasa lafiya da ke da nau'in ciwon sukari na 2 yana nuna haɗarin microvascular da rikice-rikice na koda na zuciya, yana buƙatar ingantaccen kulawa;

Kula da Kumburi da ke da alaƙa da Kiba: Matsayin Hs-CRP yana da alaƙa da alaƙa tare da tarin kitse na visceral, yana ba da ƙima mai ƙima don sa baki na rayuwa.

7. Daidaitaccen Bincike da Maganin Cututtukan Autoimmune

Ganewar kumburi na subclinical: Gano Hs-CRP zai iya taimakawa wajen gano raunuka na waje (irin su shiga cikin jini) a cikin marasa lafiya tare da cututtukan cututtuka na rheumatoid a farkon mataki, jagorancin haɗin gwiwar multidisciplinary hade;

Matsakaicin daidaitawa na burin jiyya: A ƙarƙashin haɗin gwiwar jiyya tare da ilimin halitta, ana iya amfani da matakin Hs-CRP na ƙasa da 1 mg/L azaman maƙasudin maƙasudin don cikakken taimako na kumburi.

Lamuno (Fluorescence immunoassay dandamali): CRP / Hs-CRP yanayin dual, kafa sabon ma'auni na masana'antu

Ganewar dual-core tare da sauyawa mai sassauƙa: dandamali iri ɗaya yana goyan bayan gwaje-gwajen CRP na al'ada (m lokaci) da Hs-CRP (lokaci na yau da kullun). Kawai ta hanyar sauya katunan reagent, ana iya fitar da sakamako lokaci guda a cikin mintuna 15, biyan buƙatun asibiti iri-iri.
Babban garantin aikin daidaitaccen aiki: Hankalin Hs-CRP ya kai 0.5 mg/L, daidai yana gano siginar kumburin ƙananan hankali;

Kewayon layi: CRP 0.5-200 mg/L, ba tare da haɗawa da gaggawa da yanayin kula da cututtuka na yau da kullun ba.

Karamin ƙira: Ya dace da yanayin aikace-aikacen daban-daban.

Daga Maganin Gaggawa zuwa Rigakafin: Sake Fannin Gudanar da Kumburi

Lamuno ya haɗu da gano biyu na CRP da Hs-CRP, ta hanyar iyakance iyakokin kulawa da kumburi na gargajiya. A cikin yanayin gaggawa, yana hanzarta gano tushen kamuwa da cuta kuma yana jagorantar amfani da maganin rigakafi; a fagen cututtuka na yau da kullum, yana tsinkayar abubuwan da ke faruwa na zuciya da jijiyoyin jini shekaru 10 a gaba, yana inganta aiwatar da "hana cututtuka kafin ya faru". Wannan ƙirƙira ba wai kawai tana inganta ingantaccen rabon albarkatun ƙasa a cikin kiwon lafiya ba har ma yana ba da ikon sarrafa lafiyar marasa lafiya ta hanyar ingantattun bayanai, samar da tallafin fasaha don rigakafi da tsarin kula da lafiyar jama'a.